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Which of the following agents would you use for rapid sequence intubation?

  1. Midazolam

  2. Propofol

  3. Rocuronium

  4. Sevoflurane

The correct answer is: Rocuronium

For rapid sequence intubation (RSI), the selection of agents is critical to ensure quick and safe airway management. In this context, neuromuscular blocking agents (NMBAs) play a fundamental role, and rocuronium is an effective choice due to its rapid onset and relatively short duration of action. Rocuronium acts by competitively blocking acetylcholine receptors at the neuromuscular junction, which leads to muscle relaxation and facilitation of intubation. Its rapid onset, typically within 1-2 minutes, allows for quick paralysis, thereby expediting the intubation process, which is essential in emergency situations where airway control is time-sensitive. This makes it particularly well-suited for rapid sequence intubation, where the goal is to secure the airway swiftly and minimize the risk of aspiration. While midazolam is a sedative that can be used in the context of intubation, it does not provide the neuromuscular blockade that is necessary for effective RSI. Propofol, although commonly used for induction of anesthesia, also lacks the muscle-relaxing properties needed for immediate intubation. Sevoflurane is an inhalation anesthetic that is not typically used in rapid sequence